Prof. David Mark SHORE - Eurasia Biochemical Approaches & Technologies Congress (EBAT)

Prof. David Mark SHORE


David Mark SHORE

Prof. David Mark SHORE

University of Geneva



Harvard College, B. A. Magna cum laude in Biochemical Sciences, 1977.
Stanford University, Department of Biochemistry. Ph. D., 1982. Advisor: Professor Robert L. Baldwin.
MRC Laboratory of Molecular Biology, Cambridge, England. 1982-1987. Postdoctoral fellow with Dr. Kim Nasmyth, Division of Cell Biology.

Professional Experience:

6/1975 - 6/1977 Undergraduate research student, Harvard University Medical School, Department of Microbiology and Molecular Genetics. Advisor: Prof. Richard Goldstein
10/1977 - 10/1982 Doctoral candidate, Department of Biochemistry, Stanford University. Advisor: Prof. Robert L. Baldwin
11/1982 - 7/1987 Postdoctoral fellow, MRC Laboratory of Molecular Biology, Cambridge, England. Advisor: Dr. Kim Nasmyth
7/1987 - 6/1994 Assistant Professor, Department of Microbiology, College of Physicians & Surgeons, Columbia University
7/1994 - 4/1996 Associate Professor (with tenure), Department of Microbiology, College of Physicians & Surgeons, Columbia University
4/1996 – 10/2020: Professor, Department of Molecular Biology, University of Geneva
7/2007 – 6/2010: Director, Department of Molecular Biology, University of Geneva
10/2017 – 10/2020: Director, Institute of Genetics and Genomics of Geneva (iGE3)

Fellowships and Awards

Dreyfus Foundation Research Fellowship, Harvard College, 1976.
Milton Fund Fellowship, Harvard College, 1977.
Henderson Prize for Undergraduate Honors Thesis in Biochemistry. Harvard University Department of Biochemistry and Molecular Biology, 1977.
NIH Predoctoral Fellowship, Department of Biochemistry, Stanford University, 1977 to 1982.
Jane Coffin Childs Memorial Fund Postdoctoral Fellowship, 1/83-12/85.
EMBO Postdoctoral Fellowship, 1/86-6/86.
British-American Heart Association Postdoctoral Fellowship, 7/86-7/87.
Searle Scholar Award, 7/88 to 6/91.
American Cancer Society Junior Faculty Research Award, 1/89-12/91.
Irma T. Hirschl Career Scientist Award, 1/89-12/93.
Lamport Award for Excellence in Biomedical Research, Columbia University, 1993.
Professional organizations, review boards, etc.
Member, European Molecular Biology Organization (EMBO), elected 1999.
Member, EMBO Council, 2006-2012; Vice-chair, EMBO Council 2009-2012.
Editorial board member, BMC Molecular Biology
Ad-hoc reviewer: (Institutes & Agencies) Swiss National Fund; European Research Council; Molecular Biology Study Section, National Institutes of Health (USA); Human Frontiers Science Program; EMBO; National Science Foundation (USA); Israel Science Foundation; Karolinska Institute (Sweden); AERES (France); Wellcome Trust, UK; Crick Institute, UK, ICREA, Spain; others.  Ad-hoc reviewer (Journals): Cell, Molecular Cell, Nature, Science, Genes & Development, EMBO J., MCB, MBC, Genetics, Current Biology, PNAS, Trends in Genetics, Gene, others.

Member, Life Sciences Switzerland, Genetics Society of America, American Society for Microbiology, American Association for the Advancement of Science (AAAS).

Scientific meetings organized

“Nuclear Dynamics and Chromatin” Sept. 26-29, 1999. Eurotel Victoria, Villars-sur-Ollon, Switzerland (supported by IIIème Cycle de la Suisse Romande).
“Telomeres and Genome Stability” Aug. 30 - Sept 3, 2006. Eurotel Victoria, Villars-sur-Ollon, Switzerland (support from SNF, OncoSuisse).
“EMBO Conference on Telomeres and the DNA damage response” Sept 15 - 19, 2008. Held at Eurotel Victoria, Villars-sur-Ollon, Switzerland (co-organized with Dr. Julia Cooper and Prof. Steven Jackson).
“EMBO Conference on Gene Transcription in Yeast” June 16 – 21, 2012. San Feliu, Spain. (vice-chair; Prof. Francesc Posas, chair).
“Physical Biology of Transcription” August 30, 2013. One-day symposium at University of Geneva, funded by CUSO and KGF. Organized with Prof. Sebastian Maerkl (EPFL).
“EMBO Conference on Gene Transcription in Yeast” June 14 – 19, 2014. San Feliu, Spain. (chair of meeting; Prof. F. Holstege, vice-chair).
“SKMB Gene Regulation Workshop” 1-day symposium, 1st week September 2015-2018. Lausanne, Switzerland. (co-organized with Prof. Winship Herr and others).


For detaling information

 “Ribosome Biogenesis and Cellular Proteostasis”

Ribosome biogenesis is a complex and energy-intensive process requiring tight coordination of ribosomal RNA and ribosomal protein production. Given the extremely high level of ribosome production in growing cells, defects in any step in the ribosome assembly process might cause the accumulation of unassembled (“orphan”) ribosomal proteins, leading to proteotoxic stress. Indeed, we found that mutations or drugs that interfere with ribosome assembly in yeast elicit a response that we call the ribosome assembly stress response (RASTR).  RASTR elicits very specific transcriptional reprogramming, characterised by the activation of the transcription factor Hsf1, which induces the transcription of genes encoding chaperones and proteasome components, and the concurrent down-regulation of ribosomal protein gene transcription through the condensation of their key activator protein Ifh1.  Both Hsf1 activation and Ifh1 condensation are driven by the accumulation of orphan ribosomal proteins.  Our data support a model in which the levels of newly synthesized ribosomal proteins, imported into the nucleus but not yet assembled into ribosomes, work to continuously balance Hsf1 and Ifh1 activity, thus guarding against proteotoxic stress during ribosome assembly.  We speculate that RASTR is an evolutionarily ancient regulatory mechanism that may operate in mammalian cells, where perturbations in ribosome assembly have been linked to a growing number of diseases referred to as “ribosomopathies”.